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The first component of the antioxidant effect of the gas in question is realized by the direct interaction of hydrogen with toxic oxidants, primarily hydroxyl (•OH) and peroxynitrite (ONOO − ) [30]

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In another study, treatment with intramuscular (i.m.) NAC (150 mg/kg/day) which started 6 h after the operation and lasted for 1 week prevented increases in MPO activity and MDA, improved histopathological findings, and decreased markers of lung apoptosis [101]